Vitamin E Research Today is a free monthly online journal that collates and summarizes the latest research about Vitamin E, including details on benefits, dosage, supplements, antioxidants.

Second generation of alpha-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical, and biological characterization.

López GV, Blanco F, Hernández P, Ferreira A, Piro OE, Batthyány C, González M, Rubbo H, Cerecetto H

Departamento de Química Orgánica, Facultad de Ciencias-Facultad de Química Universidad de la República, Montevideo, Uruguay.

Synthesis, physicochemical, and biological characterization of a series of alpha-tocopherol mimetics with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and mammal cytotoxic activities. The lipophilic-hydrophilic balance of all products was also evaluated. A new hybrid furoxan, phenol derivative 17, possesses adequate profile of the studied properties.

Published 30 July 2007 in Bioorg Med Chem, 15(18): 6262-72.
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