Vitamin E Research Today is a free monthly online journal that collates and summarizes the latest research about Vitamin E, including details on benefits, dosage, supplements, antioxidants.

Statins enhance circulating vitamin E.

Cangemi R, Loffredo L, Carnevale R, Pignatelli P, Violi F

Statins have been shown to inhibit oxidative stress, however it is still unclear if they influence antioxidant status. We performed a retrospective analysis of oxidative stress, as assessed by serum levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and vitamin E, a known antioxidant, in patients with metabolic syndrome (n=112) treated (n=30) or not (n=82) with statins. Statin-treated patients showed higher levels of vitamin E (p=0.02) and lower 8-OHdG (p<0.01) than statin-free patients. An inverse correlation between oxidative stress and vitamin E was observed (r=-0.670, p<0.001). These preliminary data suggest that statins enhance the antioxidant status likely by inhibiting oxidative stress.

Published 18 December 2007 in Int J Cardiol, 123(2): 172-4.
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