Vitamin E Research Today is a free monthly online journal that collates and summarizes the latest research about Vitamin E, including details on benefits, dosage, supplements, antioxidants.

Oxidative stress and changes in alpha- and gamma-tocopherol levels during coronary artery bypass grafting.

Ulus AT, Aksoyek A, Ozkan M, Katircioglu SF, Vessby B, Basu S

Sections of Geriatrics and Clinical Nutrition Research, Faculty of Medicine, Uppsala University, Uppsala, Sweden.

We studied whether cardiopulmonary bypass (CPB) has any immediate impact on the initiation of antioxidative defenses in the body by measuring F(2)-isoprostanes and alpha- and gamma-tocopherol, respectively. 8-iso-PGF(2alpha) levels increased significantly within 3 minutes and until the end of CPB. alpha-Tocopherol levels increased gradually at 20 min during CPB and continued until 6 hours after CPB. gamma-Tocopherol levels followed a similar fashion at the end of CPB. 8-iso-PGF(2alpha) and tocopherol levels kept at basal level 12 and 24 hours post CPB. These findings suggest that an increased free radical-induced oxidative stress together with a gradual appearance of antioxidative defense system during and after CPB.

Published 8 March 2005 in Ann N Y Acad Sci, 1031: 352-6.
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