Vitamin E Research Today is a free monthly online journal that collates and summarizes the latest research about Vitamin E, including details on benefits, dosage, supplements, antioxidants.

Does aging affect the response of vitamin E status to vitamin E depletion and supplementation?

Winklhofer-Roob BM, Roob JM, Maritschnegg M, Sprinz G, Hiller D, Marktfelder E, Preinsberger M, Wuga S, Sundl I, Tiran B, Cardinault N, Ribalta J, Rock E,

Human Nutrition & Metabolism Research Training Center, Institute of Molecular Biosciences, Karl-Franzens University, Schubertstrasse 1, A-8010 Graz, Austria. brigitte.winklhoferroob@uni-graz.at

A vitamin E depletion/supplementation study was conducted in 100 healthy 20-75-year-old volunteers. The responses of vitamin E status to 3-week dietary vitamin E restriction to approximately 25% of recommended intake and 2-month unrestricted dietary intake plus 800 IU/d of RRR-alpha-tocopherol were studied as a function of age. Plasma alpha-tocopherol concentrations were closely related to cholesterol concentrations, which increased with age (P < 0.001). Upon dietary restriction, plasma alpha-tocopherol concentrations decreased significantly (P < 0.001) but independently of age. Plasma alpha-tocopherol responses to supplementation increased significantly with age, but this effect disappeared after standardization for cholesterol. gamma-Tocopherol concentrations decreased to less than 30% of baseline.

Published 8 March 2005 in Ann N Y Acad Sci, 1031: 381-4.
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