Vitamin E Research Today is a free monthly online journal that collates and summarizes the latest research about Vitamin E, including details on benefits, dosage, supplements, antioxidants.

Tocopherol long chain fatty alcohols decrease the production of TNF-alpha and NO radicals by activated microglial cells.

Muller T, Grandbarbe L, Morga E, Heuschling P, Luu B

Laboratoire de chimie organique des substances naturelles, Centre de Neurochimie, UMR 7123 CNRS, Université Louis Pasteur, 67084 Strasbourg, France.

The synthesis of a series of Tocopherol long chain Fatty Alcohols (TFA) and their biological activities on the modulation of microglial activation are described. Specifically, the 2-(12-hydroxy-dodecyl)-2,5,7,8-tetramethyl-chroman-6-ol, the TFA bearing 12 carbon atoms on the side chain (n=12), shows the most potent inhibition of secretion on nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) by lipopolysaccharide (LPS)-activated microglia.

Published 19 November 2004 in Bioorg Med Chem Lett, 14(24): 6023-6.
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